تفاصيل الوثيقة نوع الوثيقة : مقال في مجلة دورية  عنوان الوثيقة : Three-dimensional reconstruction of fracture callus morphogenesis Three-dimensional reconstruction of fracture callus morphogenesis   لغة الوثيقة : الانجليزية  المستخلص : Rat and mouse femur and tibia fracture calluses were collected over various time increments of healing. Serial sections were produced at spatial segments across the fracture callus. Standard histological methods and in situ hybridization to col1a1 and col2a1 mRNAs were used to define areas of cartilage and bone formation as well as tissue areas undergoing remodeling. Computer-assisted reconstructions of histological sections were used to generate three-dimensional images of the spatial morphoge nesis of the fracture calluses. Endochondral bone formation occurred in an asymmetrical manner in both the femur and tibia, with cartilage tissues seen primarily proximal or distal to the fractures in the respective calluses of these bones. Remodeling of the calcified cartilage proceeded from the edges of the callus inward toward the fracture producing an inner-supporting trabecular structure over which a thin outer cortical shell forms. These data suggest that the specific developmental mechanisms that control the asymmetrical pattern of endochondral bone formation in fracture healing recapitulated the original asymmetry of development of a given bone because femur and tibia grow predominantly from their respective distal and proximal physis. These data further show that remodeling of the calcified cartilage produces a trabecular bone structure unique to fracture healing that provides the rapid regain in weight-bearing capacity to the injured bone.  ردمد : 0  اسم الدورية : Journal of Histochemistry & Cytochemistry  المجلد : 54  العدد : 11  سنة النشر : 2006 هـ 2006 م  نوع المقالة : مقالة علمية  تاريخ الاضافة على الموقع : Friday, January 4, 2008  الباحثون اسم الباحث (عربي) اسم الباحث (انجليزي) نوع الباحث المرتبة العلمية البريد الالكتروني ياسر الخياري Alkhiary, Yaser باحث رئيسي دكتوراه YALKHIARY@Kau.edu.sa الملفات اسم الملف النوع الوصف  Three-dimensional reconstruction of fracture callus morphogenesis.pdf pdf   الرجوع إلى صفحة الأبحاث